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Üsküdar ÜniversitesiKapat

Prof.Dr. Sevim IŞIK

MDBF / Moleküler Biyoloji ve Genetik Bölümü (İngilizce) - Bölüm Başkan Yardımcısı

sevim.isikuskudar.edu.tr

(0216) 400 2222 2462

ORCID ID: 0000-0001-7687-6082

Citation : 461 | h-index : 11 | i10-index : 11

Kısa Özgeçmiş

YÖK Formatlı CV

1995 yılında Boğaziçi Üniversitesi Moleculer Biology &Genetics Bölümü’nde tamamlamıştır. Daha sonra Cellular and Molecular Biology İnstitute, Molecular Biology Department Programı’nda 2003 yılında tamamlayarak Doktor unvanını almıştır.

Devamı

Öğrenim Durumu & Akademik Unvanlar


Yönetilen Lisansüstü Tezleri


  • Regulation of RhoGTPase dependent axonogenesis by topoisomerase IIβ in cerebellar granular neurons, 2016.
  • Real time analysis of in vitro photodynamic therapy (PDT) application in MCF-7 human breast cancer line with indocyanine green (ICG) embedded mesoporous magnetic silicon nanoparticle (MSN) molecule, 2016.
  • The association of parkinson's disease with dna topoisomerase IIβ in neural-differentiated SH-SY5Y cell line, 2015.
  • Role of DNA Topoisomerase IIβ in Rho GTPase dependent axon growth through neural differentiation of human mesenchmal stem cells, 2015.
  • Development of novel nanomaterials for non-viral gene delivery, 2015.
  • Preperation, characterization, and in vitro evaluation of chitosan/nano-zeolite porous scaffolds enriched with human mesenchymal stem cells for bone tissue enginering, 2014.
  • Association of alzheimer disease with DNA topoisomerase IIß in primary neuronal cells, 2013.
  • Osteogenic properties of bone marrow derived mesenchymal stem cells on novel nano-hydroxyapatite/chitosan composite scaffolds, 2013.
  • Investigation of chondrogenic properties of bone marrow derived mesenchymal stem cells on pamam dendrimer incorporated chitosan scaffolds, 2013.
  • Bioinformatics analysis and gene expression profile of one of the topoisomerase enzymes in Tettrahymena thermophila, 2012.

Akademik Faaliyetler > Yayınlar

(ISI Web of Science Core Collection *)

Toplam: 18
DNA topoisomerase II beta stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression
STEM CELL RESEARCH & THERAPY (2018)
Cellular model of Alzheimer’s disease: Aβ1-42 peptide induces amyloid deposition and a decrease in topo isomerase IIβ and nurr1 expression
CURRENT ALZHEIMER RESEARCH (2017)
Preparation and characterization of novel chitosan/zeolite scaffolds for bone tissue engineering applications
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2017)
Preparation and characterization of amine functional nano-hydroxyapatite/chitosan bionanocomposite for bone tissue engineering applications
Carbohydrate Polymers (2017)
Boronic Acid vs. Folic Acid: A Comparison of the bio-recognition performances by Impedimetric Cytosensors based on Ferrocene cored dendrimer
Biosensors and Bioelectronics (2017)
Highly Sensitive Detection of Cancer Cells with an Electrochemical Cytosensor Based on Boronic acid Functional Polythiophene
Biosensors and Bioelectronics (2016)
Preparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications
Biomedicine and Pharmacotherapy (2016)
DNA topoisomerase IIβ as a molecular switch in neural differentiation of mesenchymal stem cells
Annals of Hematology (2015)
Influence of gold nanoparticle architecture on in vitro bioimaging and cellular uptake
Journal of Nanoparticle Research (2014)
Delivery of lipophilic porphyrin by liposome vehicles: Preparation and photodynamic therapy activity against cancer cell lines
Photodiagnosis and Photodynamic Therapy (2014)
Ferrocene incorporated PAMAM dendrons: Synthesis, characterization, and anti-cancer activity against AGS cell line
Medicinal Chemistry Research (2013)
Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells
Annals of Hematology (2012)
Proliferative and apoptotic effects of olive extracts on cell lines and healthy human cells
Food Chemistry (2012)
Photodynamic activities of protoporphyrin IX and its dopamine conjugate against cancer and bacterial cell viability
Medicinal Chemistry Research (2011)
Comparison of long-term retinoic acid-based neural induction methods of bone marrow human mesenchymal stem cells
In vitro Cellular and developmental Biology-Animal (2011)
Steady and disturbed flow effects on human umbilical vein endothelial cells (HUVECs) in vascular system: an experimental study
ACTA OF BIOENGINEERING AND BIOMECHANICS (2010)
The SUMO pathway is required for selective degradation of DNA topoisomerase IIβ induced by a catalytic inhibitor ICRF‐1931
FEBS Letters (2003)
High incidence of antinuclear antibodies that recognize the matrix attachment region
biochemical and biophysical research communications (2001)

Akademik Faaliyetler > Yayınlar

(Diğer Bilimsel Yayınlar)

Toplam: 1
Selective silencing of DNA topoisomerase IIβ in human mesenchymal stem cells by siRNAs (small interfering RNAs)
Cell biology international reports (2011)

Akademik Faaliyetler > Kitap - Kitap Bölümü


Kitap Adı Yıl
Temel Moleküler Biyoloji: Bölüm 3 (RNA’nın Çok Yönlülüğü) Bölüm 12 (Gen Regülasyonunun Epigenetik Mekanizmaları) 2014

İdari Faaliyetler


İdari Görev Kategorisi İdari Görev Yıl
Öğrenci Danışmanlığı 41 veya üzeri Öğrenci Danışmanlığı 2019
Kurul Üyeliği Parge Yürütme Kurulu Üyeliği 2019
Komisyon Üyesi Eğitim Komisyonu Üyeliği (Enstitü / Fakülte / MYO) 2019
Komisyon Üyesi Staj Komisyonu Üyeliği (Enstitü / Fakülte / MYO) 2019

Eğitim ve Öğretim Faaliyetleri


Akademik Yıl Dersin Adı Dersin Türü
2019-2020 GÜZ Enzimoloji Lisansustu
2019-2020 GÜZ Stem Cell Technologies Lisans
2019-2020 GÜZ General Biology I Lisans
2018-2019 BAHAR Biyoetik Lisans
2018-2019 BAHAR Bioethics Lisans
2018-2019 BAHAR Bioethics Lisans
2018-2019 BAHAR Physiology Lisans
2018-2019 BAHAR Physiology Lisans

* ISI Web of Science Core Collection

  • Science Citation Index
  • Arts & Humanities Citation Index
  • Science Citation Index Expanded
  • Social Sciences Citation Index
  • Emerging Sources Citation Index