Prof.Dr. Nesrin KARTAL ÖZER

Tıp Fakültesi(İngilizce) / Tıbbi Biyokimya Anabilim Dalı / Metabolik ve İnflamatuar Hastalıklar Uygulama ve Araştırma Merkezi - Müdür

nesrin.kartalozeruskudar.edu.tr

(0216) 400 2222 / 3242

ORCID: 0000-0002-4968-3178

Documents : 79 | Citation : 3272 | h-index : 29

Citation : 5265 | h-index : 36 | i10-index : 63

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Araştırma Alanları

Endoplazmik retikulum stress, Lipit birikimi, Yüksek yağlı diyet, Yağlı karaciğer hastalığı, Metabolik hastalıklar

Araştırma Alanları İle Örtüşen BM Sürdürülebilir Kalkınma Hedef Etiketleri

3

Kısa Özgeçmiş

Prof. Dr. Nesrin KARTAL ÖZER lisans eğitimini 1977 yılında Hacettepe Üniversitesi Eczacılık Fakültesi’nde tamamlamıştır. Yüksek lisans eğitimini yine Hacettepe Üniversitesi Eczacılık Fakültesinde 1980 yılında tamamlayan Nesrin KARTAL ÖZER, Doktora eğitimini ise 1983 yılında yine Hacettepe Üniversitesi Tıbbi Biyokimya alanında tamamlamıştır. 1988 yılında Doçent Doktor, 1994 yılında ise Profesör Doktor unvanını almıştır. Prof. Dr. Nesrin KARTAL ÖZER, Üsküdar Üniversitesi Tıp Fakültesi(İngilizce) Tıbbi Biyokimya Anabilim Dalı’nda Profesör Doktor olarak görev yapmaktadır.

Devamı

Öğrenim Durumu & Akademik Unvanlar

1977

Lisans

Hacettepe Üniversitesi Eczacılık Fakültesi

1980

Yüksek Lisans

Hacettepe Üniversitesi Klinik Analiz

1983

Doktora

Hacettepe Üniversitesi, Tıp Fakültesi Biyokimya (TIP)

Doçentlik

Marmara Üniversitesi, Tıp Fakültesi Biyokimya

1988

Profesörlük

Marmara Üniversitesi, Tıp Fakültesi Biyokimya

1994

Yönetilen Lisansüstü Tezleri

  1. Lipit Birikiminde Rol Alan Seipin Proteinin Kolesterol İle İndüklenen Yağlı Karaciğer Modelinde Endoplazmik Retikulum Stres ve Otofaji Üzerine Etkisi, 2023.

Akademik Faaliyetler > Yayınlar

(Scopus) Toplam: 65

Protective effect of alpha-tocopherol on lipogenesis and oxysterol production in hypercholesterolemia-induced nonalcoholic steatohepatitis

Free Radical Research (2024)

Impact of Seipin in cholesterol mediated lipid droplet maturation; status of endoplasmic reticulum stress and lipophagy

Mechanisms of Ageing and Development (2024)

Vitamin E discussion forum position paper on the revision of the nomenclature of vitamin E

Free Radical Biology and Medicine (2023)

Protective effects of an electrophilic metabolite of docosahexaenoic acid on UVB-induced oxidative cell death, dermatitis, and carcinogenesis

Redox Biology (2023)

Cholesterol accumulation in hepatocytes mediates IRE1/p38 branch of endoplasmic reticulum stress to promote nonalcoholic steatohepatitis

Free Radical Biology and Medicine (2022)

Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases

Frontiers in Aging (2022)

High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol

IUBMB LIFE (2021)

alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis

BioFactors (2020)

High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E

BIOFACTORS (2020)

Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue

Metabolism (2020)

HSP70 Inhibition Leads to the Activation of ProteasomalSystem under Mild Hyperthermia Conditions in Young andSenescent Fibroblasts

Oxidative Medicine and Cellular Longevity (2020)

Vitamin E: Regulatory role in the cardiovascular system

IUBMB Life (2019)

High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue

Oxidative Medicine and Cellular Longevity (2018)

Antitumor and antimetastatic effects of walnut oil in esophageal adenocarcinoma cells

Clinical Nutrition (2017)

CD36 expression in peripheral blood mononuclear cells reflects the onset of atherosclerosis

BioFactors (2017)

Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review

Redox Biology (2017)

Proteasome inhibitors in cancer therapy: Treatment regimen and peripheral neuropathy as a side effect

Free Radical Biology and Medicine (2016)

Vitamin E: Emerging aspects and new directions

Free Radical Biology and Medicine (2016)

Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells

Redox Biology (2016)

Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

Mechanisms of Ageing and Development (2016)

Effect of a hypercholesterolemia as a starting factor on spinal degeneration in rabbits and role of Vitamin E (α-tocopherol)

Surgical Neurology International (2016)

Endoplasmic reticulum stress and proteasomal system in amyotrophic lateral sclerosis

Free Radical Biology and Medicine (2015)

Chemotherapy Resistance: The role of proteasomal degradation and heat shock response

Free Radical Biology and Medicine (2015)

Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases

Free Radical Biology and Medicine (2014)

The effect of Irisin on antioxidant system in liver

Free Radical Biology and Medicine (2014)

The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines

Free Radical Biology and Medicine (2014)

The role of hypercholesterolemic diet and vitamin E on Nrf2 pathway, endoplasmic reticulum stress and proteasome activity

Free Radical Biology and Medicine (2014)

Heat shock proteins and proteasomal degradation in normal and tumor cells

Free Radical Biology and Medicine (2014)

CD36 as a biomarker of atherosclerosis

Free Radical Biology and Medicine (2014)

Regulation of protein turnover by heat shock proteins

Free Radical Biology and Medicine (2014)

Molecular Function of Tocopherols in Age Related Diseases

Current Pharmaceutical Design (2014)

Effects of vitamin E on peroxisome proliferator-activated receptor γ and nuclear factor-erythroid 2-related factor 2 in hypercholesterolemia-induced atherosclerosis

Free Radical Biology and Medicine (2014)

Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis

Redox Biology (2014)

The role of heat stress on the age related protein carbonylation

Journal of Proteomics (2013)

Identification of differentially expressed proteins in atherosclerotic aorta and effect of vitamin E

Journal of Proteomics (2013)

Vitamin E attenuates homocysteine and cholesterol induced damage in rat aorta

Cardiovascular Pathology (2013)

Resveratrol: French Paradox Revisited

Frontiers in Pharmacology (2012)

Protective effects of vitamin E against hypercholesterolemia-induced age-related diseases

Genes & Nutrition (2011)

Cellular Protection and Therapeutic Potential of Tocotrienols

Current Pharmaceutical Design (2011)

Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity

Free Radical Biology and Medicine (2011)

Lipid Rafts and Redox Regulation of Cellular Signaling in Cholesterol Induced Atherosclerosis

Current Cardiology Reviews (2010)

Chromatin repair after oxidative stress: Role of PARP-mediated proteasome activation

Free Radical Biology and Medicine (2010)

Oxidative stress related changes in the brain of hypercholesterolemic rabbits

BioFactors (2009)

Report of society for free radical research Europe summer school

BioFactors (2009)

Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by interfering with MAPK kinase pathway

BioFactors (2008)

Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis: Role of vitamin E

BioFactors (2008)

The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet

Archives of Biochemistry and Biophysics (2006)

Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbits

Atherosclerosis (2005)

What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

Mechanisms of Ageing and Development (2005)

On the opinion of the European Commission ?Scientific Committee on Food? regarding the tolerable upper intake level of vitamin E (2003)

European Journal of Nutrition (2005)

Effect of vitamin E on the development of atherosclerosis

Toxicology (2000)

Age-dependent increase of collagenase expression can be reduced by α-tocopherol via protein kinase C inhibition

Free Radical Biology and Medicine (1999)

Vitamin E mediated response of smooth muscle cell to oxidant stress

Diabetes Research and Clinical Practice (1999)

Molecular basis of α-tocopherol control of smooth muscle cell proliferation

BioFactors (1998)

α-Tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state

Biochemical Journal (1998)

Effect of Vitamin E and Probucol on Dietary Cholesterol-Induced Atherosclerosis in Rabbits

Free Radical Biology and Medicine (1998)

Signalling functions of α-Tocopherol in smooth muscle cells.

International Journal for Vitamin and Nutrition Research (1997)

Dietary cholesterol-induced changes of protein kinase C and the effect of vitamin E in rabbit aortic smooth muscle cells

Atherosclerosis (1996)

The role of hydrogen peroxide and RRR-alpha-tocopherol in smooth muscle cell proliferation

Cell Death and Differentiation (1996)

Tocopherols and 6-Hydroxy-chroman-2-Carbonitrile Derivatives Inhibit Vascular Smooth Muscle Cell Proliferation by a Nonantioxidant Mechanism

Archives of Biochemistry and Biophysics (1995)

d-α-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells

FEBS Letters (1993)

d-α-tocopherol control of cell proliferation

Molecular Aspects of Medicine (1993)

Effect of chronic halothane exposure on lipid peroxidation, osmotic fragility and morphology of rat erythrocytes

Journal of Applied Toxicology (1990)

Plasma membrane potential of lymphocytes from ataxia telangiectasia patients

Clinical Biochemistry (1989)

Studies on lymphocyte cell surface in ataxia-telangiectasia

Clinical and Experimental Immunology (1985)

Akademik Faaliyetler > Yayınlar

(Diğer Bilimsel Yayınlar) Toplam: 19

Effect of High Cholesterol Diet and α-Tocopherol Supplementation on Endoplasmic Retüculum Stress and Apoptosis in Hippocampus Tissue

Clinical and Experimental Health Sciences (2022)

Deficiency of SREBP1c modulates autophagy mediated lipid droplet catabolism during oleic acid induced steatosis

Metabolism Open (2021)

SREBP1c silencing reduces endoplasmic reticulum stress and related apoptosis in oleic acid induced lipid accumulation

Marmara Medical Journal (2021)

Hypercholesterolemia increases vasospasm resulting from basilar artery subarachnoid hemorrhage in rabbits which is attenuated by Vitamin E

Surgical Neurology International (2011)

Hiperkolesterolemi ve Alzheimer Hastalığı

Turkiye Klinikleri Journal of Medical Sciences (2008)

The effect of temporary aneurysm clip on the common carotid artery of atherosclerotic rabbits

Surgical Neurology (2007)

Vitamins and Regulation of Gene Expression.

Bibliotheca Nutritio et Dieta (2001)

Vitamins and Regulation of Gene Expression

Forum of Nutrition (2001)

Effects of high cholesterol, vitamin E and Probucol on protein kinase C activity and proliferation of smooth muscle cells.

Academic Press (1999)

Homocysteine Induces DNA Synthesis and Proliferation of Vascular Smooth Muscle Cells by a Hydrogen Peroxide-Independent Mechanism

Antioxidants & Redox Signaling (1999)

A. RRR- α-tocopherol regulation of gene transcription in response to the cell oxidant status.

Z. Ernahrungwiss (1998)

Measurement of reactive oxygen species by chemiluminescence in diet-induced atherosclerosis: protective roles of vitamin E and probucol on different radical species

International Journal of Clinical & Laboratory Research (1998)

α-tocopherol as a modulator of smooth muscle cell proliferation

Prostaglandins, Leukotrienes and Essential Fatty Acids (1997)

Modulation by oxidants and antioxidants of signal transducion and smooth muscle cell proliferation.

Oxidative Stress and Signal Transduction (1997)

Vitamin E: a sensor and an information transducer of the cell oxidation state

The American Journal of Clinical Nutrition (1995)

New roles of low density lipoproteins and vitamin E in the pathogenesis of atherosclerosis

Biochemistry and molecular biology international (1995)

New roles of low density proteins and vitamin E in the pathogenesis of atherosclerosis

Biochemistry and Molecular Biology International (1995)

Vascular smooth muscle cell proliferation is controlled by d-α-tocopherol at the level of protein kinase C and of AP-1.

Oxidative Stress and Aging (1995)

Lymphocyte γ-glutamyltranspeptidase activity in ataxia-telangiectasia

Biochemical Medicine and Metabolic Biology (1986)

Akademik Faaliyetler > Editörlük

  1. Metabolism Clinical and Experimental, ISBN:The ISSN of Metabolism: Clinical and Experimental journal is 00260495, 15328600., 2015.
  2. NFS Journal, ISBN:ISSN: 23523646, 2015.
  3. IUBMB Life, ISBN:ISSN 1521-6551, 2020.
  4. FEBS Open Bio, ISBN:2211-5463, 2024.
  5. IUBMB Life, ISBN:1521-6551, 2024.
  6. FEBS Open Bio, ISBN:2211-5463, 2024.

Projeler > Projeler

  1. Alfa-13-COOH yüklü makrofaj hedefli nanopartikül etkinliğinin yağlı karaciğer hastalığında incelenmesi, 2027.
  2. Alfa-13-COOH Yüklü Makrofaj Hedefli Nanopartikül Etkinliğinin Yağlı Karaciğer Hastalığında Incelenmesi”, 2027.
  3. Yüksek kolesterol içeriğine sahip fruktoz palmitat ve trans-yağ diyeti ile indüklenen Non-Alkolik Yağlı Karaciğer hastalığından Steatohepatite geçişte ferroptozisin rolünün in vivo olarak incelenmesi, 2025.
  4. SREBP1c inhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, 2025.
  5. SREBP1c İinhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, 2025.
  6. Kolesterol ile indüklenen in vitro lipit birikimi ve in vivo NASH modellerinde NRF-2 aktivasyonunun etkisi, 2026.
  7. Kolesterol ile İndüklenen İn vitro lipit birikimi ve in vivo NASH modellerinde Nrf-2 aktivasyonunun etkisi, 2026.
  8. Garsinoik Asit ve 17-oxo-DHA'nın Inflamasyona Karşı Etkinliğinin In Vitro ve In Vivo Modeller Kullanılarak Değerlendirilmesi, 2024.
  9. Seipin Proteinin Yüksek Kolesterollü Diyet ile Indüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, 2024.
  10. Seipin Proteinin Yüksek Kolesterollü Diyet ile İndüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, 2024.

Akademik Faaliyetler > Kongre - Konferans Katılım

  1. Redox Biology: A Paradigm of the Foundation of Life, Serbian Society for Mitocondrial and Free Radical Physiology, 2024.
  2. Annual Meeting of SFRR-E 2024 From Molecules to Tissues: Redox Biology in Action, 2024.
  3. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  4. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  5. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  6. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  7. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  8. 4 th BenBedPhar Meeting From Physiology to Pathology, 2023.
  9. 10th Biennial Meeting of Society for Free Radical Research-Asia, “New Paradigm for Research on Oxidative Stress and Inflammation”,, 2022.
  10. 10th Biennial Meeting of Society for Free Radical Research-Asia, “New Paradigm for Research on Oxidative Stress and Inflammation”, 2022.
  11. 10th Biennial Meeting of Society for Free Radical Research-Asia, “New Paradigm for Research on Oxidative Stress and Inflammation”, 2022.
  12. The Korean Academy of Science and Technology, 53th symposium on ‘New Insights on the Landscape of Redox Signaling in Human Diseases, 2022.

İdari Faaliyetler

  1. Merkez Müdürü / Head of Resarch Center, METİFLAM, (2024 - Devam ediyor.)
  2. Kurul Üyeliği / Board Member, FİHADEK, (2024 - Devam ediyor.)

Eğitim ve Öğretim Faaliyetleri