Nesrin KARTAL ÖZER, Ph.D

Professor

nesrin.kartalozeruskudar.edu.tr

(0216) 400 2222 / 3242

ORCID: 0000-0002-4968-3178

Documents : 80 | Citation : 3350 | h-index : 30

Citation : 5358 | h-index : 36 | i10-index : 64

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Research Fields

Endoplasmic reticulum stress, Lipid accumulation, High fat diet, Fatty liver disease, Metabolic diseases

UN Sustainable Development Goal Labels Matching with Research Fields

3

Short CV

Nesrin Kartal Ozer, is Professor at Uskudar University, Faculty of Medicine, Department of Biochemistry, Istanbul,Turkey. She graduated with a BSc in Pharmacy from Hacettepe University, Ankara, Turkey and she has received her PhD in Biochemistry in Hacettepe University, Faculty of Medicine. She moved then to Marmara University, Istanbul and worked there until 2022. She was a Visiting Scientist at St.George’s Hospital, Medical School, Department of Biochemistry, London, UK (1985-1986); Institute of Biochemistry and Molecular Biology, University of Bern, Switzerland (1993-2004) and University of Hohenheim, Stuttgart, Germany (2008). In her research she published more than 100 articles and she was invited speaker at ~80 international meetings. She was the organizer ~10 scientific meetings and conferences. As member of International Organizations, it is worth mentioning her membership in the International Advisory Committee, Oxygen Club of California (1999- today); FEBS Advanced Course Committee Member (2003-2006); FEBS Fellowships Committee Member (2021-2024), Secretary General Society for Free Radical Research-Europe (SFRR-E) and Member of the Council (2003-2009) and President of SFRR-E (2013-2014). She was awarded The Oxygen Club of California Award and “Life Time Honorary Member” in 2006 “In recognition of outstanding research contributions on the role of vitamin E in atherosclerosis and to fostering the field of free radical biology” and The Society for Free Radical Research-Europe Lifetime Achievement Award in 2019 “In recognition of Lifetime Extraordinary Scientific Achievements in the Field of Free Radical Research”. Her research focus on endoplasmic reticulum stress, redox signaling and cell death in metabolism related diseases such as cardiovascular diseases and non-alcoholic fatty liver disease. In parallel she has carried out research on the molecular function of tocopherols in these diseases.

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Education Status & Academic Titles

1977

Undergraduate Degree

Hacettepe Üniversitesi Eczacılık Fakültesi

1980

Master Degree

Hacettepe Üniversitesi Klinik Analiz

1983

Doctorate

Hacettepe Üniversitesi, Tıp Fakültesi Biyokimya (TIP)


Associate Professorship

Marmara Üniversitesi, Tıp Fakültesi Biyokimya

1988

Professorship

Marmara Üniversitesi, Tıp Fakültesi Biyokimya

1994

Supervised Graduate Theses

  1. Lipit Birikiminde Rol Alan Seipin Proteinin Kolesterol İle İndüklenen Yağlı Karaciğer Modelinde Endoplazmik Retikulum Stres ve Otofaji Üzerine Etkisi, 2023.

Academic Activities > Publications

(Scopus) Toplam: 66

Modulation of inflammatory signaling by vitamin E metabolites and its therapeutic implications

Free Radical Research (2025)

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Protective effect of alpha-tocopherol on lipogenesis and oxysterol production in hypercholesterolemia-induced nonalcoholic steatohepatitis

Free Radical Research (2024)

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Impact of Seipin in cholesterol mediated lipid droplet maturation; status of endoplasmic reticulum stress and lipophagy

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Mechanisms of Ageing and Development (2024)

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Vitamin E discussion forum position paper on the revision of the nomenclature of vitamin E

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Free Radical Biology and Medicine (2023)

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Protective effects of an electrophilic metabolite of docosahexaenoic acid on UVB-induced oxidative cell death, dermatitis, and carcinogenesis

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Redox Biology (2023)

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Cholesterol accumulation in hepatocytes mediates IRE1/p38 branch of endoplasmic reticulum stress to promote nonalcoholic steatohepatitis

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Free Radical Biology and Medicine (2022)

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Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases

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Frontiers in Aging (2022)

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High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol

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IUBMB LIFE (2021)

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alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis

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BioFactors (2020)

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High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E

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BIOFACTORS (2020)

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Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue

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Metabolism (2020)

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HSP70 Inhibition Leads to the Activation of ProteasomalSystem under Mild Hyperthermia Conditions in Young andSenescent Fibroblasts

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Oxidative Medicine and Cellular Longevity (2020)

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Vitamin E: Regulatory role in the cardiovascular system

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IUBMB Life (2019)

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High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue

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Oxidative Medicine and Cellular Longevity (2018)

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Antitumor and antimetastatic effects of walnut oil in esophageal adenocarcinoma cells

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Clinical Nutrition (2017)

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CD36 expression in peripheral blood mononuclear cells reflects the onset of atherosclerosis

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BioFactors (2017)

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Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review

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Redox Biology (2017)

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Proteasome inhibitors in cancer therapy: Treatment regimen and peripheral neuropathy as a side effect

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Free Radical Biology and Medicine (2016)

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Vitamin E: Emerging aspects and new directions

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Free Radical Biology and Medicine (2016)

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Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells

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Redox Biology (2016)

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Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

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Mechanisms of Ageing and Development (2016)

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Effect of a hypercholesterolemia as a starting factor on spinal degeneration in rabbits and role of Vitamin E (α-tocopherol)

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Surgical Neurology International (2016)

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Endoplasmic reticulum stress and proteasomal system in amyotrophic lateral sclerosis

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Free Radical Biology and Medicine (2015)

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Chemotherapy Resistance: The role of proteasomal degradation and heat shock response

Free Radical Biology and Medicine (2015)

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Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases

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Free Radical Biology and Medicine (2014)

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The effect of Irisin on antioxidant system in liver

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Free Radical Biology and Medicine (2014)

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The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines

Free Radical Biology and Medicine (2014)

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The role of hypercholesterolemic diet and vitamin E on Nrf2 pathway, endoplasmic reticulum stress and proteasome activity

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Free Radical Biology and Medicine (2014)

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Heat shock proteins and proteasomal degradation in normal and tumor cells

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Free Radical Biology and Medicine (2014)

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CD36 as a biomarker of atherosclerosis

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Free Radical Biology and Medicine (2014)

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Regulation of protein turnover by heat shock proteins

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Free Radical Biology and Medicine (2014)

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Molecular Function of Tocopherols in Age Related Diseases

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Current Pharmaceutical Design (2014)

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Effects of vitamin E on peroxisome proliferator-activated receptor γ and nuclear factor-erythroid 2-related factor 2 in hypercholesterolemia-induced atherosclerosis

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Free Radical Biology and Medicine (2014)

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Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis

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Redox Biology (2014)

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The role of heat stress on the age related protein carbonylation

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Journal of Proteomics (2013)

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Identification of differentially expressed proteins in atherosclerotic aorta and effect of vitamin E

Journal of Proteomics (2013)

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Vitamin E attenuates homocysteine and cholesterol induced damage in rat aorta

Cardiovascular Pathology (2013)

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Resveratrol: French Paradox Revisited

Frontiers in Pharmacology (2012)

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Protective effects of vitamin E against hypercholesterolemia-induced age-related diseases

Genes & Nutrition (2011)

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Cellular Protection and Therapeutic Potential of Tocotrienols

Current Pharmaceutical Design (2011)

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Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity

Free Radical Biology and Medicine (2011)

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Lipid Rafts and Redox Regulation of Cellular Signaling in Cholesterol Induced Atherosclerosis

Current Cardiology Reviews (2010)

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Chromatin repair after oxidative stress: Role of PARP-mediated proteasome activation

Free Radical Biology and Medicine (2010)

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Oxidative stress related changes in the brain of hypercholesterolemic rabbits

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Report of society for free radical research Europe summer school

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Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by interfering with MAPK kinase pathway

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Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis: Role of vitamin E

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The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet

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Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbits

Atherosclerosis (2005)

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What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

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On the opinion of the European Commission ?Scientific Committee on Food? regarding the tolerable upper intake level of vitamin E (2003)

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Effect of vitamin E on the development of atherosclerosis

Toxicology (2000)

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Age-dependent increase of collagenase expression can be reduced by α-tocopherol via protein kinase C inhibition

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Vitamin E mediated response of smooth muscle cell to oxidant stress

Diabetes Research and Clinical Practice (1999)

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Molecular basis of α-tocopherol control of smooth muscle cell proliferation

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α-Tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state

Biochemical Journal (1998)

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Effect of Vitamin E and Probucol on Dietary Cholesterol-Induced Atherosclerosis in Rabbits

Free Radical Biology and Medicine (1998)

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Signalling functions of α-Tocopherol in smooth muscle cells.

International Journal for Vitamin and Nutrition Research (1997)

Dietary cholesterol-induced changes of protein kinase C and the effect of vitamin E in rabbit aortic smooth muscle cells

Atherosclerosis (1996)

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Tocopherols and 6-Hydroxy-chroman-2-Carbonitrile Derivatives Inhibit Vascular Smooth Muscle Cell Proliferation by a Nonantioxidant Mechanism

Archives of Biochemistry and Biophysics (1995)

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d-α-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells

FEBS Letters (1993)

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d-α-tocopherol control of cell proliferation

Molecular Aspects of Medicine (1993)

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Effect of chronic halothane exposure on lipid peroxidation, osmotic fragility and morphology of rat erythrocytes

Journal of Applied Toxicology (1990)

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Plasma membrane potential of lymphocytes from ataxia telangiectasia patients

Clinical Biochemistry (1989)

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Studies on lymphocyte cell surface in ataxia-telangiectasia

Clinical and Experimental Immunology (1985)

Academic Activities > Publications

(Other Scientific Publications) Toplam: 19

Hiperkolesterolemi ve Alzheimer Hastalığı

Turkiye Klinikleri Journal of Medical Sciences (2008)

Vitamins and Regulation of Gene Expression.

Bibliotheca Nutritio et Dieta (2001)

α-tocopherol as a modulator of smooth muscle cell proliferation

Prostaglandins, Leukotrienes and Essential Fatty Acids (1997)

New roles of low density proteins and vitamin E in the pathogenesis of atherosclerosis

Biochemistry and Molecular Biology International (1995)

Lymphocyte γ-glutamyltranspeptidase activity in ataxia-telangiectasia

Biochemical Medicine and Metabolic Biology (1986)

Academic Activities > Editörlük

  1. Metabolism Clinical and Experimental, ISBN:The ISSN of Metabolism: Clinical and Experimental journal is 00260495, 15328600., 2015.
  2. NFS Journal, ISBN:ISSN: 23523646, 2015.
  3. IUBMB Life, ISBN:ISSN 1521-6551, 2020.
  4. FEBS Open Bio, ISBN:2211-5463, 2024.
  5. IUBMB Life, ISBN:1521-6551, 2024.
  6. FEBS Open Bio, ISBN:2211-5463, 2024.

Projects > Projects

  1. Alfa-13-COOH yüklü makrofaj hedefli nanopartikül etkinliğinin yağlı karaciğer hastalığında incelenmesi, 2027.
  2. Alfa-13-COOH Yüklü Makrofaj Hedefli Nanopartikül Etkinliğinin Yağlı Karaciğer Hastalığında Incelenmesi”, 2027.
  3. Yüksek kolesterol içeriğine sahip fruktoz palmitat ve trans-yağ diyeti ile indüklenen Non-Alkolik Yağlı Karaciğer hastalığından Steatohepatite geçişte ferroptozisin rolünün in vivo olarak incelenmesi, 2025.
  4. SREBP1c inhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, 2025.
  5. SREBP1c İinhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, 2025.
  6. Kolesterol ile indüklenen in vitro lipit birikimi ve in vivo NASH modellerinde NRF-2 aktivasyonunun etkisi, 2026.
  7. Kolesterol ile İndüklenen İn vitro lipit birikimi ve in vivo NASH modellerinde Nrf-2 aktivasyonunun etkisi, 2026.
  8. Garsinoik Asit ve 17-oxo-DHA'nın Inflamasyona Karşı Etkinliğinin In Vitro ve In Vivo Modeller Kullanılarak Değerlendirilmesi, 2024.
  9. Seipin Proteinin Yüksek Kolesterollü Diyet ile Indüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, 2024.
  10. Seipin Proteinin Yüksek Kolesterollü Diyet ile İndüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, 2024.

Academic Activities > Congress - Conference Participation

  1. Redox Biology: A Paradigm of the Foundation of Life, Serbian Society for Mitocondrial and Free Radical Physiology, 2024.
  2. Annual Meeting of SFRR-E 2024 From Molecules to Tissues: Redox Biology in Action, 2024.
  3. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  4. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  5. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  6. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  7. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  8. 4 th BenBedPhar Meeting From Physiology to Pathology, 2023.
  9. 10th Biennial Meeting of Society for Free Radical Research-Asia, “New Paradigm for Research on Oxidative Stress and Inflammation”,, 2022.
  10. 10th Biennial Meeting of Society for Free Radical Research-Asia, “New Paradigm for Research on Oxidative Stress and Inflammation”, 2022.
  11. 10th Biennial Meeting of Society for Free Radical Research-Asia, “New Paradigm for Research on Oxidative Stress and Inflammation”, 2022.
  12. The Korean Academy of Science and Technology, 53th symposium on ‘New Insights on the Landscape of Redox Signaling in Human Diseases, 2022.

Administrative Activities

  1. Merkez Müdürü / Head of Resarch Center, METİFLAM, (2024 - Devam ediyor.)
  2. Kurul Üyeliği / Board Member, FİHADEK, (2024 - Devam ediyor.)

Education and Training Activities

  1. Medical Committee Courses (Committee 3A), (Undergraduate Degree / 2023-2024 Güz)
  2. Medical Committee Courses (Com 2A), (Undergraduate Degree / 2023-2024 Güz)