Prof. S.Tuncel ÖZDEN Pharmacogenetic Laboratory

Therapeutic Drug Blood Level (TDM) analyzes and phenotyping studies have been successfully carried out in order to understand the personal response to the pesticides with Agilent 6410B and Agilent 6470 high-performance liquid chromatography-coupled tandem mass spectrometry (LC-MS / MS) devices are used for the first time in the Clinical Pharmacogenetics Laboratory of Üsküdar University.

Therapeutic Drug Blood level monitoring (TDM) is the best way to optimize pharmacotherapy. The TDM clinician provides the opportunity to adjust the dose of the drug to the patient's personal characteristics. Another benefit of follow-up with TDM is that the disease in which the response to treatment is inadequate when using the maximal dose of medication is helpful in determining slowly metabolized drugs in patients with toxic effects when receiving minimal doses. While determining the unexpected toxicity in normal treatment doses is beneficial, high doses and abuse of medicines are also prevented. In our laboratory, TDM quantity determination analyzes of 64 antipsychotic drug molecules are performed routinely.

In phenotyping studies, in addition to the genetic structure of the individual, the effects of nutrition, exercise, cigarette consumption and other drugs used in the treatment, which are also called life style of the individual, are evaluated. In our laboratory, the activities of the major enzymes responsible for drug metabolism (Cyp1A2, Cyp2D6, Cyp3A4) are determined by indirect analysis with probe drug applications.

 

Molecule Name 

Time to reach steady state (Css)

 

1

Acomprosate

2-3 days

2

Agomelatine

2-3 days

3

Alprazolam

3 days

4

Amisulpiride

3 days

5

Amitriptiline + Nortriptiline

4-16 days

6

Aripiprazole

14 days

7

Asenapine

5 days

8

Atomoxetine

2 days

9

Buprenorfin + Norbuprenorfin

2 days

10

Buspirone

2 days

11

Biperiden

3-5 days

12

Bupropion

7-10 days

Bupropion+ hydroxbupropin

7-10 days

13

Carbamazepine

4-12 days

14

Chlorpromazine

2-7 days

15

Citalopram

7 days

16

Clomipramine

7-8 days

17

Clonazepam

5-7 days

18

Clozapine

2 days

19

Clozapine+ norclozapine

20

Diazepam

10-20 days

21

Disülfiram

2 days

22

Donapezil

17-21 days

23

Duloxetine HCL

3 days

24

Escitalopram

7 days

25

Fluoxetine

20 days

26

Flupentixol

7 days

27

Fluvoxamine

8 days

28

Fluphenazine

3-4 days

29

Gabapentine

1-2 days

30

Haloperidol

5-8 days

31

İmipramine + desipramine

2-4 days

32

Lacosamide

1-2 days

33

Lamotrigine

5-7 days

34

Levetiracetam

1-2 days

35

Lityum

 

36

Lorazepam

2-3 days

37

Maprotiline

6-12 days

38

Memantine

12-17 days

39

Methylphenidate

1-2 days

40

Metformin 

1-2 days

41

Mianserine

2-13 days

42

Mirtazapine

3-4 days

43

Milnacipran

2 days

44

Moclobemide

1 days

45

Modafinil

1-2 days

46

Naltrexone

2 days

Naltrexone+ beta naltrexol

47

Olanzapine

7 days

48

Opipramol

2-3 days

49

Oxcarbamazepine Metabolite (MHD)

2-4 days

50

Paliperidone

4-5 days

51

Paroxetine

3-4 days

52

Pimozide

11 days

53

Pramipexole

2-3 days

54

Pregabaline

1-2 days

55

Quetiapine

2 days

56

Reboxetine

2-3 days

57

Risperidone + 9-OHRis

1-5 days

58

Rivastigmine

2-3 days

59

Sertindole

13-15 days

60

Sertraline

7 days

61

Sulpiride

2 days

62

Tianeptine Sodyum

2 days

63

Topiramate

5 days

64

Trazodone HCL

1-2 days

65

Trifluoperazine

5-8 days

66

Valproic Acid (total)

2-4 days

67

Valproic Acid serbest)

2-4 days

68

Venlafaxine

3  days

69

Vortioxetine

2 weeks

70

Ziprasidone

2  days

71

Zonisamide

7 days

72

Zuclopenthixol

5  days

Prof. S.Tuncel ÖZDEN Pharmacogenetic Laboratory 200 m2 alana sahiptir.

Device Type

Device Number

LC-MS/MS

1

Deionize Water Purification Unit

1

Ultrasonic Bath

1

Shaking Drying Oven

2

Multi Vorteks-Mixer

1

Drying Oven

2

Cooled Centrifuge

1

Microbalances

2

Heat Cycle Device

1

Nanodrop Spectrophotometer

1

Centrifugal

3

Cooled Centrifuge

1

Horizontal and vertical electrophoresis (Tank + power supply)

1

Western blot system (tank + power supply)

1

Imaging System (DNA-RNA Protein)

1

Homojenizatör

1

Real- time PCR (Roche nano)

1

Microwave

1

Security Cabine

1

Block Heater

1

Automatic Mixer

1

Drying Oven with CO2

1

Automatic Pipette Set

2

-20, -70, -80, +4 freezer

4

Nitrogen Generator

1

Uğur ATİK Uğur ATİK, Ph.D
Professor of Biochemistry
 
VSHS / Medical Laboratory
Prof. Uğur Atik is a Clinical Biochemist. Graduated from Faculty of Pharmacy at Ankara University in 1968. He took his Ph.D. degree at Gulhane Military Medical Academy (GATA), Faculty of Medicine, Department of Biochemistry in 1980 .Has worked at the ... [ » ]
Uğur ATİK / (0216) 400 2222 - : 2994
Selma ÖZİLHAN Selma ÖZİLHAN,  
Advanced Toxicology Laboratory Analysis In-Charge
Ms. Özilhan was Born in 1954 in Ordu. She graduated from the Ankara High School for Girls. She completed her graduate studies at the Faculty of Pharmacy of Hacettepe University and holds an M.Sc. degree in the field of Bağlantıpharmacognosy from Gazi ... [ » ]
Selma ÖZİLHAN / (0216) 400 2222 - : 2996
Fadime CANBOLAT Fadime CANBOLAT, CV
Lecturer Fadime Canbolat was born in İstanbul in 1982. She graduated from Selçuk University Faculty of Science, Chemistry Department in 2004. In 2007, Selçuk University Institute of Health  Sciences has completed a master's degree in Pharmacolog ... [ » ]
Fadime CANBOLAT / (0216) 400 22 22 - : 2997
Murat ÖZDEMİR Murat ÖZDEMİR,  
[...]
Murat ÖZDEMİR / (0216) 400 2222
Aykut Kul Aykut Kul,  
[...]
Aykut Kul / (0216) 400 2222 - : 2998
Ceren ŞAHİN Ceren ŞAHİN ,  
[...]
Ceren ŞAHİN / (0216) 400 2222