Cell Culture Laboratory

In the Cell Culture Laboratory, studies are being made to develop anticancer drugs in numerous cancer cell lines. To investigate the mechanism of action of drug-carrying substances, target genes are repressed by retrovirus plasmids to study the signal pathways in the cell.

Furthermore, neuron culture is performed, and the molecular mechanism of neuron differentiation is studied. Cellular modelling of autism is performed. Biopsy studies are also performed in mammalian cells.

Studies carried out in the Cell Culture laboratory:

• Atasever Arslan B, Yilancioglu K, Timucin AC, Kalkan Z, Gur H, Deniz E, Erman B, Cetiner S. Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes. Eur J Pharm Sci. 2016;83:120-131.
• Kalkan Z, Durasi IM, Sezerman U, Atasever Arslan B. Potential of GRID2 receptor gene for preventing TNF-induced neurodegeneration in autism. Neurosci Lett. 2016;620:62-9.
• Salcini C, Atasever-Arslan B, Sunter G, Gur H, Isik FB, Saylan CC, Yalcin AD. High Plasma Pentraxin 3 Levels in Diabetic Polyneuropathy Patients with Nociceptive Pain. Tohoku J Exp Med. 2016;239(1):73-9.
• Atasever Arslan B, Yilancioglu K, Bekaroglu MG, Taskin E, Altinoz E, Cetiner S. Cytotoxic Effect of Extract from Dunaliella salina against SH-SY5Y Neuroblastoma Cells. Gen Physiol Biophys.2015;34(2):201-207.
• Farooqi AA, Attar R, Arslan BA, Romero MA, ul Haq MF, Qadir MI. Recently Emerging Signaling Landscape of Ataxia-telangiectasia Mutated Kinase (ATM). Asian Pac J Cancer Prev. 2014; 15(16): 6485-8.
• Kalkan Z, Gür H, Atasever Arslan B. Recent Studies on Genetic and Environmental Basis of Autism. JNBS. 2014;1(3):92-94.
• Bekaroglu MG, Atasever Arslan B. Natural Killer (NK) Cells in b Thalassemia Major Patients. JSM Biotechnol Bioeng 2015; 2(2):1040.