Tuğçe DEMİREL YALÇINER, MD

Assistant Professor

tugce.demirelyalcineruskudar.edu.tr

(0216) 400 2222 /

ORCID: 0000-0002-6540-882X

Documents : 10 | Citation : 136 | h-index : 5

Citation : 64 | h-index : 5 | i10-index : 3

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Research Fields

Endoplasmic reticulum stress, lipid accumulation, high fat diet, fatty liver diseases, metabolic diseases

UN Sustainable Development Goal Labels Matching with Research Fields

3

Short CV

I completed my undergraduate education in Istanbul Culture University, Department of Molecular Biology and Genetics in 2015. After completing my   master's   degree   in   Marmara   University   Faculty   of   Medicine, Department of Medical Biochemistry in 2017, I completed my doctorate in the   same   department   in   2023.   During   my   master's   and   doctorate education, I have TÜBİTAK supported projects and publications in the field of metabolic diseases and fatty liver diseases.

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Education Status & Academic Titles

2015

Undergraduate Degree

İstanbul Kültür Üniversitesi Moleküler Biyoloji ve Genetik

2017

Master Degree

Marmara Üniversitesi Tıbbi Biyokimya

2023

Doctorate

Marmara Üniversitesi Tıbbi Biyokimya

Academic Activities > Publications

(Scopus) Toplam: 8

Protective effect of alpha-tocopherol on lipogenesis and oxysterol production in hypercholesterolemia-induced nonalcoholic steatohepatitis

Free Radical Research (2024)

Impact of Seipin in cholesterol mediated lipid droplet maturation; status of endoplasmic reticulum stress and lipophagy

Mechanisms of Ageing and Development (2024)

Cholesterol accumulation in hepatocytes mediates IRE1/p38 branch of endoplasmic reticulum stress to promote nonalcoholic steatohepatitis

Free Radical Biology and Medicine (2022)

Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases

Frontiers in Aging (2022)

High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol

IUBMB LIFE (2021)

alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis

BioFactors (2020)

Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue

Metabolism (2020)

Vitamin E: Regulatory role in the cardiovascular system

IUBMB Life (2019)

Academic Activities > Publications

(Other Scientific Publications) Toplam: 3

Effect of High Cholesterol Diet and α-Tocopherol Supplementation on Endoplasmic Retüculum Stress and Apoptosis in Hippocampus Tissue

Clinical and Experimental Health Sciences (2022)

Deficiency of SREBP1c modulates autophagy mediated lipid droplet catabolism during oleic acid induced steatosis

Metabolism Open (2021)

SREBP1c silencing reduces endoplasmic reticulum stress and related apoptosis in oleic acid induced lipid accumulation

Marmara Medical Journal (2021)

Projects > Projects

  1. Alfa-13-COOH yüklü makrofaj hedefli nanopartikül etkinliğinin yağlı karaciğer hastalığında incelenmesi, 2027.
  2. Alfa-13-COOH Yüklü Makrofaj Hedefli Nanopartikül Etkinliğinin Yağlı Karaciğer Hastalığında Incelenmesi”, 2027.
  3. SREBP1c inhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, 2025.
  4. SREBP1c İinhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, 2025.
  5. Kolesterol ile indüklenen in vitro lipit birikimi ve in vivo NASH modellerinde NRF-2 aktivasyonunun etkisi, 2026.
  6. Kolesterol ile İndüklenen İn vitro lipit birikimi ve in vivo NASH modellerinde Nrf-2 aktivasyonunun etkisi, 2026.
  7. Seipin Proteinin Yüksek Kolesterollü Diyet ile Indüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, 2024.
  8. Seipin Proteinin Yüksek Kolesterollü Diyet ile İndüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, 2024.

Academic Activities > Congress - Conference Participation

  1. Redox Biology: A Paradigm of the Foundation of Life, Serbian Society for Mitocondrial and Free Radical Physiology, 2024.
  2. Annual Meeting of SFRR-E 2024 From Molecules to Tissues: Redox Biology in Action, 2024.
  3. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.
  4. SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, 2024.

Administrative Activities

  1. Merkez Müdür Yardımcısı / Deputy Head of Research Center, METİFLAM Müdür Yardımcısı, (2024 - Devam ediyor.)

Education and Training Activities