Nigar KANTARCI ÇARŞIBAŞI, Ph.D

Assistant Professor

nigar.carsibasiuskudar.edu.tr

(0216) 400 2222 / 2463

ORCID: https://orcid.org/0000-0003-1013-6668

Citation : 1420 | h-index : 6 | i10-index : 6

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Research Fields

Computer-aided drug design, Protein engineering, Protein-protein and protein-drug interactions, Protein modeling, Polymer Technology and Engineering.

UN Sustainable Development Goal Labels Matching with Research Fields

3 4 9

Short CV

Born in 1979 in Istanbul, Dr. Nigar Kantarcı Çarşıbaşı completed her high school education at Eyüboğlu Science High School between 1994-1997 and graduated with first place. She completed her undergraduate education at Boğaziçi University, Department of Chemical Engineering in 2001. Between 2001 and 2003, she continued her master's degree in Boğaziçi Chemical Engineering, and during this time she conducted hydrodynamic and heat transfer studies on the "Bubble Column Reactor" that she designed and installed. Dr. Kantarcı Çarşıbaşı has 2 articles published in SCI from her master's thesis studies. She carried out her doctoral studies at Boğaziçi Chemical Engineering Polymer Research Center between 2003-2009. Kantarcı Çarşıbaşı worked on short protein chains that bind to metals by molecular dynamics simulation within the scope of her doctoral studies. In another study, she conducted modeling studies on the p53 protein, an important tumor suppressor protein, and its interaction with DNA. Within the scope of her doctoral thesis, she modeled the conformational transitions of proteins using a mathematical modeling technique she developed, and by combining the Anisotropic Network Model with the Monte Carlo Technique, she investigated the transition pathways for many proteins from open to closed, from free to bound form. Dr. Nigar Kantarcı Çarşıbaşı has 4 articles published in SCI within the scope of his doctoral studies. She still continues her studies at Üsküdar University, Faculty of Engineering and Natural Sciences, Department of Chemical Engineering. Dr. Kantarcı Çarşıbaşı's academic research areas are: bioinformatics, protein modeling, protein-protein interactions, protein-structure-function relationship, computer aided drug design.

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Education Status & Academic Titles

2001

Undergraduate Degree

Boğaziçi Üniversitesi Kimya Mühendisliği

2003

Master Degree

Boğaziçi Üniversitesi Kimya Mühendisliği

2009

Doctorate

Boğaziçi Üniversitesi Kimya Mühendisliği

Supervised Graduate Theses

  1. Nutrasötik moleküllerin pankreas kanserindeki etkinliklerinin in siliko ve in vitro tekniklerle araştırılması, 2024.
  2. Investigation of the effect of temperature and electrolytic properties on heat transfer and conductivity in aqueous salt solutions, 2024.
  3. Alzheimer Hastalığının tedavisinde doğal kaynaklı ve FDA onaylı moleküllerin asetilkolinesteraz enziminin inhibasyonu için in siliko ve in vitro tekniklerle araştırılması, 2023.
  4. Kanser tedavisinde Murine Double Minute 2 proteininin inhibasyonu için ligand-bazlı farmakofor modelleme tekniği ile yeni moleküllerin tasarımı, 2022.

Academic Activities > Publications

(Scopus) Toplam: 11

Competitive Inhibition and Synergistic Effects of Nutraceutical and Metabolite Molecules on Anti-Acetylcholinesterase Activity

Journal of the Turkish Chemical Society Section A: Chemistry (2024)

Identification of the Candidate mGlu2 Allosteric Modulator THRX-195518 through In Silico Method and Evaluation of Its Neuroprotective Potential against Glutamate-Induced Neurotoxicity in SH-SY5Y Cell Line

Current Issues in Molecular Biology (2024)

Queuine as a potential multi-target drug for alzheimer’s disease: insights from protein dynamics

Journal of Biomolecular Structure and Dynamics (2023)

Proposing novel natural compounds against Alzheimer’s disease targeting acetylcholinesterase

PLOS ONE (2023)

Elucidation of Conformational Dynamics of MDM2 and Alterations Induced Upon Inhibitor Binding Using Elastic Network Simulations and Molecular Docking

Journal of Computational Biophysics and Chemistry (2021)

Features of large hing-bending conformational transitions. Prediction of closed structure from open state

Biophysical Journal (2014)

Conformational transition pathways explored by monte carlo simulation integrated with collective modes

Biophysical Journal (2008)

Cooperative fluctuations point to the dimerization interface of P53 core domain

Biophysical Journal (2006)

A Study on Hydrodynamics and Heat Transfer in a Bubble Column Reactor with Yeast and Bacterial Cell Suspensions

The Canadian Journal of Chemical Engineering (2005)

Bubble Column Reactors

Process Biochemistry (2005)

Molecular Dynamics Simulations on constraint metal binding peptides

Polymer (2005)

Academic Activities > Publications

(Other Scientific Publications) Toplam: 1

Konformasyonel Dinamik Yönlendirmeli Farmakofor Modelleme ile Güçlü Antikanser Ajanlarının Belirlenmesi

Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi (2022)

Academic Activities > Book - Book Chapter

(Other) Toplam: 2
  1. Natural Source Drug Molecules Targeting Alzheimer’s Disease, Nigar Kantarcı Çarşıbaşı, Platanus Publishing, 2023
  2. COMPUTER AIDED DRUG DESIGN: LINKING SIMULATION WITH MEDICINE, Nİgar ÇarŞibaŞi, Efe Akademik Publishing, 2022

Projects > Projects

  1. Kimya Mühendisliğinde Temel Proses Ekipmanlarının Kurulumu ve Uygulamaları, 2024.
  2. Kimya Mühendisliğinde Temel Proses Ekipmanlarının Kurulumu ve Uygulamaları, 2024.
  3. Kimya Mühendisliğinde Temel Proses Ekipmanlarının Kurulumu ve Uygulamaları, 2024.
  4. Yeşil Kimya ile Sentezlenen Altın ve Seryum Oksit Nanopartiküllerin Nöroprotektif Etkisinin İn Vivo ve İn Vitro Şartlarda Değerlendirilmesi, 2023.
  5. Yeşil Kimya ile Sentezlenen Altın ve Seryum Oksit Nanopartiküllerin Nöroprotektif Etkisinin İn Vivo ve İn Vitro Şartlarda Değerlendirilmesi, 2024.
  6. Alzheimer Hastalığının tedavisinde doğal kaynaklı ve FDA onaylı moleküllerin asetilkolinesteraz enziminin inhibasyonu için in siliko ve in vitro tekniklerle araştırılması, 2023.
  7. Alzheimer Hastalığının tedavisinde doğal kaynaklı ve FDA onaylı moleküllerin asetilkolinesteraz enziminin inhibasyonu için in siliko ve in vitro tekniklerle araştırılması, 2023.
  8. İn Silico Analiz ile Aday mglu2 Pozitif Allosterik Modülatörün Bulunması ve Nöroprotektif Etkisinin In Vitro Ortamda Değerlendirilmesi, 2023.
  9. In Silico Analiz ile Aday mglu2 Positif Allosterik Modülatörün Bulunması ve Nöroprotektif Etkisinin In Vitro Ortamda Değerlendirilmesi, 2023.

Academic Activities > Congress - Conference Participation

  1. 5th International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2024), 2024.
  2. 5th International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2024), 2024.
  3. 12.Uluslararası İlaç Kimyası kongresi, 2024.
  4. 7th International Conference on Innovative Studies of Contemporary Sciences, 2023.
  5. 11th International Drug Chemistry Congress, 2023.
  6. The Sixth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-6), 2022.
  7. 2. Computer-Aided Drug Design Symposium and Workshop-Linking Design, Biology, Chemistry and Medicine, 2022.
  8. 4th International Conference on Biological and Chemical Sciences, 2021.
  9. 23th International Conference on Drug Discovery, Design, Development and Optimization, 2021.
  10. 8th multidisciplinary cancer research congress, 2021.

Administrative Activities

  1. Ana Bilim Başkanı / Head of Department, Biyoinformatik, (2024 - Devam ediyor.)
  2. Öğrenci Danışmanlığı / Student Adviser, 81-90 Öğrenci Danışmanlığı, (2023 - Devam ediyor.)
  3. Komisyon Üyesi / Member of Commission, Kalite Komisyonu (Enstitü / Fakülte / MYO), (2022 - Devam ediyor.)
  4. Koordinatör / Coordinator, Erasmus Bölüm Koordinatörlüğü, (2022 - 2023)
  5. Öğrenci Kulübü Danışmanlığı / Head of Student Club, Kimya-Biyoloji Mühendisliği Kulübü, (2022 - Devam ediyor.)
  6. Çalışma Grubu Üyelikleri / Research Group Membership, Nörogenetik Çalışma Grubu, (2022 - Devam ediyor.)
  7. Bölüm Başkan Yardımcısı / Deputy Head of Department, Kimya-Biyoloji Mühendisliği (İngilizce) Bölüm Başkan Yardımcısı, (2021 - Devam ediyor.)
  8. Komisyon Üyesi / Member of Commission, Eğitim Komisyonu (Enstitü / Fakülte / MYO), (2019 - Devam ediyor.)

Education and Training Activities