Fatma Gizem AVCI, Ph.D.

Assistant Professor

fatmagizem.avciuskudar.edu.tr

(0216) 400 2222 / 0

ORCID: 0000-0001-6618-0487

Documents : 18 | Citation : 269 | h-index : 9

Citation : 447 | h-index : 12 | i10-index : 13

: 17
: 0

Research Fields

Antibiotic Resistance, Industrial Biotechnology, Omic Technologies, Metabolic Engineering, Protein Engineering

UN Sustainable Development Goal Labels Matching with Research Fields

3 6 7 9

Short CV

Fatma Gizem Avci received her B.Sc. (2010) and M.Sc. (2013) degrees from the Department of Bioengineering, Ege University. During her M.Sc. studies, she focused on the production of 1,3-propanediol (1,3-PDO) using a cell recycle bioreactor. She received a scholarship from Erasmus Exchange Programme and participated in a project on the production of 1,3-PDO using the metabolic engineering approach for 3 months at the Centre for Industrial Biotechnology and Biocatalysis, Ghent University, Belgium. She completed her Ph.D. at the Department of Bioengineering, Marmara University in 2018. Her research during her Ph.D. was mainly focused on antibiotic resistance mechanisms, investigation of antimicrobial candidates specifically from plant-derived compounds, and understanding their mechanism of action. With support from of FEMS Research Fellowship, she also carried out studies on the characterization of bacterial membrane proteins at the National Scientific Research Center (CNRS-Centre National de la Recherche Scientifique) in Lyon, France.
Fatma Gizem Avci is currently an Assistant Professor at Uskudar University, Bioengineering Department, Turkey. Her research areas include antibiotic resistance, protein engineering, metabolic engineering, omic technologies, and industrial biotechnology.

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Education Status & Academic Titles

2010

Undergraduate Degree

Ege Üniversitesi Biyomühendislik

2013

Master Degree

Ege Üniversitesi Biyomühendislik

2018

Doctorate

Marmara Üniversitesi Biyomühendislik (İngilizce)

Supervised Graduate Theses

  1. Investigation of the Antivirulence Agents Targeting the Type IV Pili, 2023.

Academic Activities > Publications

(Scopus) Toplam: 19

Antivirulence therapy: type IV pilus as a druggable target for bacterial infections

Medicinal Chemistry Research (2024)

Phycoremediation: a path towards heavy metal bioremediation from wastewater

Journal of Chemical Technology & Biotechnology (2024)

Unraveling bacterial stress responses: implications for next-generation antimicrobial solutions

World Journal of Microbiology and Biotechnology (2024)

Attenuation of Type IV pili activity by natural products

Journal of Biomolecular Structure and Dynamics (2024)

A review on the mechanistic details of OXA enzymes of ESKAPE pathogens

Pathogens and Global Health (2022)

Carvacrol Enhances the Antimicrobial Potency of Berberine in Bacillus subtilis

Current Microbiology (2022)

Identification of novel inhibitors of the ABC transporter BmrA

Bioorganic Chemistry (2020)

Potentiating the activity of berberine for Staphylococcus aureus in a combinatorial treatment with thymol

Microbial Pathogenesis (2020)

Repurposing bioactive aporphine alkaloids as efflux pump inhibitors

Fitoterapia (2019)

What Are the Multi-Omics Mechanisms for Adaptation by Microorganisms to High Alkalinity? A Transcriptomic and Proteomic Study of a Bacillus Strain with Industrial Potential

OMICS: A Journal of Integrative Biology (2018)

Membrane active peptides and their biophysical characterization

Biomolecules (2018)

Targeting a hidden site on class A beta-lactamases

Journal of Molecular Graphics and Modelling (2018)

An OMIC approach to elaborate the antibacterial mechanisms of different alkaloids

Phytochemistry (2017)

Transcriptomic analysis displays the effect of (-)-roemerine on the motility and nutrient uptake in Escherichia coli

Current Genetics (2017)

Response of Escherichia coli to Prolonged Berberine Exposure

Microbial Drug Resistance (2016)

An evolutionarily conserved allosteric site modulates beta-lactamase activity

Journal of Enzyme Inhibition and Medicinal Chemistry (2016)

High yield 1, 3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii

Microbial Cell Factories (2016)

1, 3-propanediol production with Citrobacter werkmanii DSM17579: effect of a dhaD knock-out

Microbial Cell Factories (2014)

The effects of cell recycling on the production of 1, 3-propanediol by Klebsiella pneumoniae

Bioprocess and Biosystems Engineering (2013)

Academic Activities > Publications

(Other Scientific Publications) Toplam: 2

Curvularia lunata: A fungus for possible berberine transformation

International Journal of Secondary Metabolite (2022)

Evaluation of silibinin as an efflux pump inhibitor in Bacillus subtilis

International Journal of Secondary Metabolite (2021)

Academic Activities > Book - Book Chapter

(Other) Toplam: 3
  1. Modeling the Microbial Cells for Biotechnological Applications, Fatma Ece Altınışık Kaya, Fatma Gizem Avcı, IGI Global, 2023
  2. Antibacterial and antifungal activities of isoquinoline alkaloids of the Papaveraceae and Fumariaceae families and their implications in structure–activity relationships, Fatma Gizem Avci, Basak Atas, Gizem Gulsoy Toplan, Caglayan Gurer, Bernasariyar Akbulut, Elsevier, 2021
  3. Fermente Ürünler Teknolojisi ve Mikrobiyolojisi- Antibiyotik Üretimi, Fatma Gizem Avcı, Nihat Alpagu Sayar, Berna Sarıyar Akbulut, Nobel Akademik Yayıncılık, 2020

Projects > Projects

  1. ESKAPE patojenlerinde yaygın bulunan D-sınıfı beta-laktamazlara karşı ortak inhibitörlerin belirlenmesi, 2026.
  2. Tip 4 pili protein kompleksinin inhibisyonu ve inhibisyon dinamiğinin karakterizasyonu, 2023.

Academic Activities > Congress - Conference Participation

  1. 13th International CeBiTec Research Conference Bielefeld, 2024.
  2. 19th European Congress on Biotechnology 2024, 2024.
  3. 47th FEBS Congress, 2023.
  4. 8th International BAU Drug Design Congress, 2022.
  5. 4th Eurasia Biochemical Approaches & Technologies Congress (EBAT), 2022.
  6. FEMS Conference on Microbiology 2022, 2022.
  7. 9. Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, 2020.
  8. MuTaLig COST ACTION CA15135 4th WG meeting, 2020.

Administrative Activities

  1. Komisyon Üyesi / Member of Commission, Strateji Geliştirme Koordinatörlüğü Komisyonu, (2024 - Devam ediyor.)
  2. Öğrenci Danışmanlığı / Student Adviser, 41-50 Öğrenci Danışmanlığı, (2023 - 2024)
  3. Ana Bilim Başkanı / Head of Department, Biyomühendislik, (2022 - 2024)
  4. Bölüm Başkanlığı / Head of Department, Biyomühendislik (İngilizce), (2022 - 2024)
  5. Laboratuvar, Laboratuvar Sorumlusu, (2022 - 2024)
  6. Çalışma Grubu Koordinatörlüğü / Coordinator of Research Group, Biyomühendislik Çalışma Grubu, (2022 - 2024)
  7. Koordinatör / Coordinator, Erasmus Koordinatörlüğü (Enstitü / Fakülte / MYO), (2022 - 2024)
  8. Kurul Üyeliği / Board Member, Enstitü Kurulu Üyeliği, (2022 - 2024)
  9. Kurul Üyeliği / Board Member, Fakülte Kurulu Üyeliği, (2022 - 2024)
  10. Koordinatör / Coordinator, ARGEYEP Koordinatörlüğü (Enstitü / Fakülte / MYO), (2022 - 2024)
  11. Öğrenci Danışmanlığı / Student Adviser, 31-40 Öğrenci Danışmanlığı, (2022 - 2023)
  12. Komisyon Üyesi / Member of Commission, Bologna Komisyonu, (2022 - 2024)
  13. Komisyon Üyesi / Member of Commission, Mezuniyet Komisyonu (Enstitü / Fakülte / MYO), (2022 - 2024)
  14. Bölüm Başkan Yardımcısı / Deputy Head of Department, Biyomühendislik (İngilizce) Bölüm Başkan Yardımcısı, (2021 - 2022)
  15. Çalışma Grubu Üyelikleri / Research Group Membership, Biyomühendislik Çalışma Grubu, (2020 - Devam ediyor.)
  16. Öğrenci Danışmanlığı / Student Adviser, 41-50 Öğrenci Danışmanlığı, (2019 - 2022)
  17. Komisyon Üyesi / Member of Commission, Staj Komisyonu (Enstitü / Fakülte / MYO), (2019 - 2021)
  18. Komisyon Üyesi / Member of Commission, Kalite Komisyonu (Enstitü / Fakülte / MYO), (2019 - 2022)
  19. Komisyon Üyesi / Member of Commission, Eğitim Komisyonu (Enstitü / Fakülte / MYO), (2019 - 2021)

Education and Training Activities

  1. Physical Chemistry, (Undergraduate Degree / 2023-2024 Güz)
  2. İlaç Biyoteknolojisi, (Master / 2023-2024 Güz)
  3. Graduation Project, (Undergraduate Degree / 2023-2024 Güz)
  4. Introduction to Biotechnology, (Undergraduate Degree / 2023-2024 Güz)