Polyamines are aliphatic molecules containing 2, 3 or 4 amino groups that are widely distributed in nature and living organisms. In the nervous system, they interact with G proteins, protein kinases, nucleotide cyclases and receptors as well as neurotransmitter systems such as catecholamines, GABA, nitric oxide and glutamate. The polyamine stress response (PSR) is a well-recognized approach that recognizes that stressful stimuli cause significant changes in polyamine metabolism and levels.
A disruption in the signal transduction system following physical, sensory or hormonal stressors causes the PSR. Polyamine stress has been associated with many neuropsychiatric disorders, including suicidal behavior, depression and schizophrenia (Fiori and Turecki, 2008). Recently, evidence pointing to a relationship between agmatine, which is considered as a new polyamine neurotransmitter, and PSS and especially schizophrenia has been obtained (Uzbay et al., 2010; 2013). When current findings are combined with previous data, it is understood that an increase in polyamine may trigger serious mental problems. There is also some preliminary evidence pointing to an association between PSY and anxiety, Parkinson's and Alzheimer's disease. However, the role and importance of PSM in neuropsychiatric disorders has not been adequately discussed.
The focus of this working group is to develop projects and studies on the relationship between polyamines, PSY and neuropsychiatric disorders. The priority area is the relationship between polyamines and schizophrenia.
