Two projects, advised by Prof. Dr. Sevim Işık from Üsküdar Üniversitesi Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, for thesis and project guidance, have been awarded support. The project, to be supported within the scope of the Turkish Health Institutes Presidency (TÜSEB) A2-01 Project Call for Master's Students, will also investigate innovative methods to reduce neuroinflammation, which plays a critical role in the development of neurodegenerative diseases for which no cure has yet been found.
Üsküdar Üniversitesi postgraduate students have added another success to their achievements.
Master's students' projects awarded support
Sedra Alhelwani and Sajeda Osman, students of the Institute of Science Molecular Biology (English) Master's program, have been awarded support for their projects within the scope of the TÜSEB A2-01 Project Call for Master's Students.
In the project advised by Prof. Dr. Sevim Işık from the Department of Molecular Biology and Genetics for thesis and project guidance, students will investigate innovative methods to reduce neuroinflammation, which plays a critical role in the development of neurodegenerative diseases for which no cure has yet been found.
In vitro efficacy of red onion-derived exosomes against neuroinflammation to be investigated…
The team of the project titled 'Investigation of the Efficacy of Red Onion-Derived Exosomes on LPS-Induced Neuroinflammation in Human Microglia HMC3 Cell Line' includes:
Sedra Alhelwani, Master's Student and Project Coordinator,
Üsküdar Üniversitesi Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Prof. Dr. Sevim Işık,
Prof. Dr. Fikrettin Şahin, Head of the Department of Genetics and Bioengineering, Yeditepe Üniversitesi Faculty of Engineering, Dr. Mehtap Aydın,
Prof. Dr. Mehmet Şenel, Head of the Department of Biochemistry, Biruni Üniversitesi.
Molecular Biology Master's Student Sedra Alhelwani will investigate the in vitro efficacy of red onion-derived exosomes against neuroinflammation in her project, carried out in partnership with Yeditepe Üniversitesi and Biruni Üniversitesi.
Project objectives include reducing inflammation-promoting cytokine levels and enzyme activities
The team of the project titled 'Investigation of the Anti-inflammatory Effect of Quercetin-Enriched Cord-Derived Mesenchymal Stem Cell Exosomes in an LPS-Induced HMC3 Microglia Neuroinflammation Model' includes:
Sajeda Osman, Master's Student and Project Coordinator,
Thesis and Project Advisor Prof. Dr. Sevim Işık from Üsküdar Üniversitesi Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics,
Assoc. Prof. Dr. Gülen Melike Demirbolat from Acıbadem Üniversitesi Faculty of Pharmacy, Department of Pharmaceutical Technology.
In her project, carried out in collaboration with Acıbadem Üniversitesi, Sajeda Osman will investigate the effects of quercetin-enriched exosomes derived from umbilical cord stem cells in reducing neuroinflammation in in vitro microglia cells.
Project objectives include reducing inflammation-promoting cytokine levels and enzyme activities.
An important foundation for future research is anticipated
Both studies aim to explore the synergistic potential of exosomes and plant-derived bioactive compounds by enriching exosomes with antioxidants in reducing neuroinflammation and treating neurodegenerative diseases. With successful results, it is anticipated that an important foundation for future research in this area can be established.